Harry Kim in 'Non Sequitur' refuses a life that fits perfectly but isn't his - not because the alternative is bad, but because he didn't arrive there honestly. On the thread vs. the contents, earned meaning vs. gifted meaning, and the hardest refusal of all: the one where everything says yes and only your own history says no.
Harry Kim wakes up on Earth with everything he ever wanted - a career, a fiancée, a future - and knows, with the certainty of someone forged in the Delta Quadrant, that it isn't his. The replaced-self: a timeline where Danny Byrd died in Harry's place and Harry got the life that doesn't belong to him. Cosimo as temporal flask. Paris as suture conductor, staying behind on an exploding runabout to conduct his friend home.